A common coding variant in CASP8 is associated with breast cancer risk

A Cox; AM Dunning; M Garcia-Closas; S Balasubramanian; MWR Reed; KA Pooley; S Scollen; C Baynes; BAJ Ponder; S Chanock; J Lissowska; L Brinton; B Peplonska; MC Southey; JL Hopper; MRE McCredie; GG Giles; O Fletcher; N Johnson; I Dos Santos Silva; L Gibson; SE Bojesen; BG Nordestgaard; CK Axelsson; D Torres; U Hamann; C Justenhoven; H Brauch; J Chang-Claude; S Kropp; A Risch; S Wang-Gohrke; P Schürmann; N Bogdanova; T Dörk; R Fagerholm; K Aaltonen; C Blomqvist; H Nevanlinna; S Seal; A Renwick; MR Stratton; N Rahman; S Sangrajrang; D Hughes; F Odefrey; P Brennan; AB Spurdle; G Chenevix-Trench; J Beesley; A Mannermaa; J Hartikainen; V Kataja; VM Kosma; FJ Couch; JE Olson; EL Goode; A Broeks; MK Schmidt; FBL Hogervorst; LJVT Veer; D Kang; KY Yoo; DY Noh; SH Ahn; S Wedrén; P Hall; YL Low; J Liu; RL Milne; G Ribas; A Gonzalez-Neira; J Benitez; AJ Sigurdson; DL Stredrick; BH Alexander; JP Struewing; PDP Pharoah; DF Easton

Journal article

A common coding variant in CASP8 is associated with breast cancer risk

A Cox, AM Dunning, M Garcia-Closas, S Balasubramanian, MWR Reed, KA Pooley, S Scollen, C Baynes, BAJ Ponder, S Chanock, J Lissowska, L Brinton, B Peplonska, MC Southey, JL Hopper, MRE McCredie, GG Giles, O Fletcher, N Johnson, I Dos Santos Silva Show all

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2007

DOI: 10.1038/ng1981

Abstract

The Breast Cancer Association Consortium (BCAC) has been established to conduct combined case-control analyses with augmented statistical power to try to confirm putative genetic associations with breast cancer. We genotyped nine SNPs for which there was some prior evidence of an association with breast cancer: CASP8 D302H (rs1045485), IGFBP3 -202 C → A (rs2854744), SOD2 V16A (rs1799725), TGFB1 L10P (rs1982073), ATM S49C (rs1800054), ADH1B 3′ UTR A → G (rs1042026), CDKN1A S31R (rs1801270), ICAM5 V301I (rs1056538) and NUMA1 A794G (rs3750913). We included data from 9-15 studies, comprising 11,391-18,290 cases and 14,753-22,670 controls. We found evidence of an association with breast cancer fo..

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